CentiScaPe
user guide page
Centralities
for Cytoscape
CentiScaPe
1.0 plug-in for Cytoscape
Complex
biological networks, such as intracellular signaling networks, are
modeled by the evolution to accomplish a variety of different
regulatory functions. This is achieved by controlling the overall
topology of the network which, then, affects its dynamic behavior.
Biological networks are hierarchichal, scale-free, modular structure
in which few nodes, the hubs, play a particularly relevant
topological role and this may reflect a critical role at biological
level. However, also nodes with no or lower hub role may have
critical regulatory role in certain biological phenomena. This could
reflect node-specific topological properties. Thus, it is of interest
to categorize every nodes in a network by means of topological
parameters allowing scoring of the nodes according to their
individual topological relevance. Computation of centrality indexes
may accomplish this goal. The centrality indexes are topological
parameters allowing a node-by-node quantification of the reciprocal
relationship between the nodes. This provides a classification of the
nodes according to their capability to influence the function of
other nodes in the network. Combination of this analysis with
experimental data (node attributes) may help to identify critical
nodes and regulatory circuits in a context-specific manner.
Start
Download of
the CentisCaPe
userguide.
Start
Download of
the centralities
tutorial.