CentiScaPe download page

CentiScaPe download page

Centralities for Cytoscape

Home spa CentiScaPe project

CentiScaPe 1.1 plug-in for Cytoscape

Complex biological networks, such as intracellular signaling networks, are modeled by the evolution to accomplish a variety of different regulatory functions. This is achieved by controlling the overall topology of the network which, then, affects its dynamic behavior. Biological networks are hierarchal, scale-free, modular structure in which few nodes, the hubs, play a particularly relevant topological role and this may reflect a critical role at biological level. However, also nodes with no or lower hub role may have critical regulatory role in certain biological phenomena. This could reflect node-specific topological properties. Thus, it is of interest to categorize every nodes in a network by means of topological parameters allowing scoring of the nodes according to their individual topological relevance. Computation of centrality indexes may accomplish this goal. The centrality indexes are topological parameters allowing a node-by-node quantification of the reciprocal relationship between the nodes. This provides a classification of the nodes according to their capability to influence the function of other nodes in the network. Combination of this analysis with experimental data (node attributes) may help to identify critical nodes and regulatory circuits in a context-specific manner.

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If you publish your results obtained with CentiScaPe1.1 plug-in please cite us!!!

"Analyzing biological network parameters with CentiScaPe"
Giovanni Scardoni; Michele Petterlini; Carlo Laudanna
Bioinformatics 2009; doi: 10.1093/bioinformatics/btp517

This directory contains a copy of the Cytoscape CentiScaPe1.1 PlugIn.

1. Copy all the .jar files in the /plugin directory to your
[Cytoscape_Home]/plugins directory.

2. Restart Cytoscape from the command line. For example, run:
cytoscape.sh or cytoscape.bat.

For any questions concerning this plugin, please contact:

Giovanni Scardoni : giovanni.scardoni AT gmail.com

This software is made available under the GPL (General Public License).
You have only to cite it if you publish some results obtained with CentiScaPe1.1 plug-in.

Enjoy!